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Candida haemulonii Species Complex: A Mini-review
Elaine Cristina Francisco1,2, Auke Wiebren de Jong2,3, Arnaldo Lopes Colombo4,5
1Division of Infectious Diseases, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, 04039-032, Brazil.
Mycopathologia
|June 30, 2023
Summary
The Candida haemulonii species complex (CHSC) is a growing threat, causing difficult-to-treat yeast infections. This review covers recent epidemiology, diagnosis, and treatment of CHSC infections.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Candida haemulonii species complex (CHSC) are emerging multidrug-resistant yeast pathogens.
- CHSC cause life-threatening invasive candidiasis in at-risk populations globally.
- Recent data show a rise in CHSC prevalence from 0.9% to 1.7% between 2008 and 2019.
Purpose of the Study:
- To provide a mini-review of recent aspects of CHSC infections.
- To address the epidemiology, diagnosis, and therapy of CHSC.
- To highlight the increasing global health concern posed by CHSC.
Main Methods:
- Literature review of recent studies on CHSC.
- Analysis of epidemiological data from medical centers.
- Synthesis of current diagnostic and therapeutic strategies.
Main Results:
- CHSC prevalence increased significantly between 2008 and 2019.
- CHSC infections are associated with high mortality in vulnerable patients.
- Emerging resistance patterns complicate treatment options.
Conclusions:
- CHSC represents a significant and growing challenge in clinical mycology.
- Improved diagnostics and novel therapeutic approaches are urgently needed.
- Continued surveillance and research are crucial to combat CHSC infections worldwide.
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