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Optofluidic force induction as a process analytical technology
Marko Šimić1,2,3, Christian Neuper4,5, Ulrich Hohenester6
1Brave Analytics GmbH, Stiftingtalstraße 14, Graz, 8010, Styria, Austria. marko.simic@uni-graz.at.
Analytical and Bioanalytical Chemistry
|July 1, 2023
Summary
Optofluidic Force Induction (OF2i) enables real-time monitoring of nanoparticle processes. This technique tracks dynamic changes in particle systems, improving quality control for manufacturers.
Area of Science:
- Materials Science
- Chemical Engineering
- Analytical Chemistry
Background:
- Nanoparticle manufacturing requires real-time process monitoring for quality control.
- Offline characterization methods lack the temporal resolution for dynamic process changes.
- Optofluidic Force Induction (OF2i) offers a solution for real-time, high-throughput particle analysis.
Purpose of the Study:
- To apply OF2i to polydisperse and multimodal particle systems.
- To monitor particle ensemble evolution over extended time scales.
- To demonstrate OF2i's utility for process feedback in diverse applications.
Main Methods:
- Utilized Optofluidic Force Induction (OF2i) for optical real-time counting.
- Applied OF2i to oil-in-water emulsions and silicon carbide nanoparticles.
- Developed a novel process feedback parameter based on particle agglomerate dissociation.
Main Results:
- Real-time detection of transitions in high-pressure homogenization states for emulsions.
- Successful monitoring of evolutionary processes in polydisperse and multimodal particle systems.
- Demonstrated OF2i's capability to provide dynamic process feedback.
Conclusions:
- OF2i provides single particle sensitivity and high throughput for nanoparticle characterization.
- OF2i is a versatile tool for real-time process monitoring and feedback.
- The technique enhances quality control in nanoparticle production.
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