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Bidirectional causal relationship between depression and frailty: a univariate and multivariate Mendelian
Ni Sang1, Bo-Han Li1, Meng-Yao Zhang1
1School of Nursing, Anhui Medical University, 15 Feicui Road, Hefei 230032, Anhui, China.
Age and Ageing
|July 1, 2023
Summary
This study used Mendelian randomization to investigate the causal link between depression and frailty. Findings confirm a bidirectional causal relationship, suggesting depression increases frailty risk and vice versa.
Area of Science:
- Gerontology
- Psychiatry
- Genetic Epidemiology
Background:
- Existing cohort studies present inconsistent findings on the bidirectional association between depression and frailty.
- A robust investigation into the causal relationship is needed.
Purpose of the Study:
- To investigate the causal relationship between depression and frailty using a bidirectional two-sample Mendelian randomization (MR) study.
Main Methods:
- Performed univariate and multivariate bidirectional MR analyses.
- Selected independent genetic variants for depression and frailty as instrumental variables.
- Employed inverse variance weighted (IVW), MR-Egger, weighted median, weighted mode, and multivariable MR (MVMR) methods, adjusting for confounders like BMI, age at menarche, and waist-to-hip ratio.
Main Results:
- Univariate MR analysis indicated a positive causal link between depression and frailty risk (OR=1.30) and between frailty and depression risk (OR=1.69).
- MVMR analysis confirmed the bidirectional causal association persisted after adjusting for potential confounders individually and in combination.
Conclusions:
- The study findings support a causal relationship between genetically predicted depression and frailty in both directions.
- This highlights the complex interplay between mental health and physical aging.
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