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Updated: Jul 24, 2025

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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Crotonylation and disease: Current progress and future perspectives

Ping Yang1, Yuanyuan Qin1, Lisha Zeng2

  • 1Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000 Sichuan, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou 646000 Sichuan, China; Sichuan Clinical Research Center for Nephropathy, Luzhou 646000 Sichuan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 1, 2023
PubMed

Insights

Histone crotonylation, a post-translational modification, shows distinct functions from acetylation. Research highlights its roles in reproduction, development, and disease, offering new therapeutic strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Epigenetics

Background:

  • Histone lysine crotonylation is a recently identified post-translational modification.
  • Crotonylation shares regulatory factors with acetylation but possesses unique biological functions due to its chemical structure.

Purpose of the Study:

  • To review recent advancements in understanding histone and nonhistone crotonylation.
  • To explore the regulatory mechanisms and disease associations of crotonylation.
  • To identify future research directions and therapeutic potentials.

Main Methods:

  • Literature review of recent studies on crotonylation.
  • Analysis of regulatory enzymes and targets.
  • Examination of crotonylation's role in biological processes and diseases.

Main Results:

  • Crotonylation plays significant roles in reproduction, development, and various diseases.
  • Specific biological functions of crotonylation are suggested by its unique chemical structure.
  • Overlap exists with acetylation pathways, but distinct mechanisms are evident.

Conclusions:

  • Crotonylation is a crucial epigenetic modification with implications for health and disease.
  • Further research into crotonylation's regulatory factors and disease links is warranted.
  • Crotonylation presents novel targets for disease intervention and treatment development.
Keywords:
Crotonyl-CoACrotonylationHistone

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