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Plasmapheresis technology.

R O Gilcher

    Vox Sanguinis
    |January 1, 1986
    PubMed
    Summary

    Automated plasmapheresis offers faster, safer blood collection than manual methods. While costly for source plasma, it efficiently produces safer fresh frozen plasma from single donors.

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    Area of Science:

    • Biomedical Engineering
    • Transfusion Medicine

    Background:

    • Manual plasmapheresis is a global practice for obtaining source plasma for fractionation into albumin, clotting factors, and gamma globulin.
    • Both paid and volunteer donors are utilized in manual plasmapheresis procedures.

    Purpose of the Study:

    • To evaluate the efficiency and safety of automated plasmapheresis technologies compared to manual methods.
    • To assess the cost-effectiveness of automated plasmapheresis for producing source plasma and fresh frozen plasma.

    Main Methods:

    • Development and utilization of automated plasmapheresis devices employing centrifugal and membrane separation technologies.
    • Comparison of automated systems (e.g., Haemonetics PCS, Organon Teknika PLASMAPUR, HemaScience Autopheresis-C) with manual plasmapheresis.

    Main Results:

    • Automated plasmapheresis is significantly faster and safer for donors than manual techniques.
    • High software costs currently limit the cost-efficiency of automated technology for source plasma production.
    • Automated technology is cost-efficient for generating fresh frozen plasma, offering a single-donor 500 ml product.

    Conclusions:

    • Automated plasmapheresis enhances donor safety and procedure speed.
    • Current automated systems are not cost-efficient for large-scale source plasma production due to high initial investment.
    • Automated plasmapheresis provides a safer, cost-efficient alternative for single-donor fresh frozen plasma, reducing patient exposure to multiple donors.

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