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Updated: Jul 24, 2025

Potentiodynamic Corrosion Testing
Published on: September 4, 2016
Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total
Alican Beba1,2, Stephanie M Peterson2, Peter C Brennan3
1George Washington University, Columbian College of Arts and Sciences, Washington, DC, USA.
Abstract:
Total joint arthroplasty (TJA) implants are composed of metals, ceramics, and/or polyethylene. Studies suggest that the debris released from metal implants may possess neurotoxic properties with reports of neuropsychiatric symptoms and memory deficits, which could be relevant to Alzheimer's disease and related dementias. This exploratory study examined the cross-sectional correlation of blood metal concentrations with cognitive performance and neuroimaging findings in a convenience sample of 113 TJA patients with history of elevated blood metal concentrations of either titanium, cobalt and/or chromium. Associations with neuroimaging measures were observed but not with cognitive scores. Larger studies with longitudinal follow-up are warranted.
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