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Related Experiment Video

Updated: Jul 24, 2025

Investigating Intestinal Barrier Breakdown in Living Organoids

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

Improving intestinal inflammaging to delay aging? A new perspective.

Lan Zhang¹, Junbin Yan², Chi Zhang³

¹Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310000, China.

Mechanisms of Ageing and Development

|July 2, 2023

Summary

Aging populations face gut health challenges. Chronic inflammation, known as inflammaging, drives gut aging and related issues. This study investigates targeting gut inflammaging to reverse aging-like gut phenotypes.

Keywords:

Aging Anti-aging Anti-inflammatory therapies Chronic inflammation Intestinal barrier Intestine

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Area of Science:

Gerontology
Gastroenterology
Immunology

Background:

The aging population presents significant social and health challenges.
Gut aging contributes to systemic health decline, affecting nutrient absorption and organ function via gut-brain and gut-liver axes.
Chronic inflammation, or inflammaging, is increasingly recognized as a key factor in aging processes.

Purpose of the Study:

To elucidate the mechanisms of inflammaging within the aging gut.
To investigate if interventions targeting gut inflammaging can reverse aging-associated gut phenotypes.

Main Methods:

Analysis of gut microbiome composition.
Assessment of gut immune function.
Evaluation of intestinal barrier integrity in the context of inflammaging.

Main Results:

Gut microbiome dysbiosis, impaired immune function, and compromised barrier integrity are linked to gut inflammaging.
Inflammaging exacerbates aging-like phenotypes in the gut through inflammatory mediators.
The study explores the potential for mitigating these phenotypes by addressing gut inflammaging.

Conclusions:

Inflammaging is a critical driver of gut aging and associated pathologies.
Targeting gut inflammaging presents a potential therapeutic strategy to counteract age-related gut dysfunction.