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Related Experiment Video

Updated: Jul 24, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Adipokines in interstitial lung diseases.

M Zielinski1, A Chwalba1, D Jastrzebski1

  • 1Department of Lung Diseases and Tuberculosis, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.

Respiratory Physiology & Neurobiology
|July 2, 2023
PubMed
Summary

Adipokine levels differ in patients with interstitial lung diseases (ILD), including idiopathic pulmonary fibrosis (IPF) and sarcoidosis, compared to healthy individuals. These findings suggest adipokines could serve as biomarkers and therapeutic targets for ILD.

Keywords:
AdipokinesAdipose tissueInterstitial lung diseases

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Area of Science:

  • Pulmonology
  • Endocrinology
  • Biochemistry

Background:

  • Interstitial lung diseases (ILD) are complex respiratory conditions with multifactorial origins.
  • Emerging research highlights the involvement of adipose tissue and adipokines in various disease processes, including lung pathologies.

Purpose of the Study:

  • To investigate serum concentrations of specific adipokines (apelin, adiponectin, chemerin) and their receptor (CMKLR1) in patients with idiopathic pulmonary fibrosis (IPF) and sarcoidosis.
  • To compare these levels against those found in healthy control subjects.

Main Methods:

  • Quantitative analysis of adipokine and receptor levels in patient cohorts and healthy controls.
  • Comparative statistical analysis to identify significant differences in concentrations.

Main Results:

  • Elevated adiponectin levels were observed in all ILD patients compared to healthy controls.
  • Apelin concentrations were significantly higher in ILD patients than in healthy subjects.
  • Chemerin and CMKLR1 levels showed a similar trend, peaking in sarcoidosis patients.

Conclusions:

  • Significant alterations in adipokine profiles are evident in patients with ILD, including IPF and sarcoidosis.
  • Adipokines represent potential diagnostic biomarkers and therapeutic targets for managing interstitial lung diseases.