Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genetic Lingo

Genetic Lingo

Aneurysm I: Introduction

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Allergic Reactions

Allergic Reactions

Angina I: Introduction

Angina I: Introduction

Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clarifications for "Managing Angioedema".

Annals of emergency medicine·2026

Same author

Beyond access: improving real-world naloxone use to address the opioid overdose epidemic.

International journal of emergency medicine·2026

Same author

Single-step versus multi-step intranasal naloxone devices for overdose response: A randomized usability study in an at-risk population.

The American journal of emergency medicine·2026

Same author

Response to Correspondence on "Precipitated Withdrawal Following Emergency Department-initiated Buprenorphine: A Retrospective Study.

Journal of addiction medicine·2026

Same author

Estimating the Need for Naloxone Distribution from United States Emergency Departments.

Journal of the American College of Emergency Physicians open·2026

Same author

Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients: A Pragmatic, Randomized Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Search research articles

Related Experiment Video

Updated: Jul 24, 2025

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

Hereditary Angioedema.

R Gentry Wilkerson¹, Joseph J Moellman²

¹Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA.

Immunology and Allergy Clinics of North America

|July 2, 2023

Summary

Hereditary angioedema (HAE) is a rare genetic disorder causing swelling attacks due to low C1-INH. Emergency physicians must understand HAE pathophysiology for prompt airway assessment and management.

Keywords:

Bradykinin C1-inhibitor Complement Difficult airway Hereditary angioedema Quincke disease

More Related Videos

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jul 24, 2025

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Published on: June 13, 2025

Area of Science:

Genetics and Immunology
Emergency Medicine

Background:

Hereditary angioedema (HAE) is a rare autosomal dominant disorder.
It results from decreased functional C1-inhibitor (C1-INH) levels.
HAE causes intermittent swelling in subcutaneous or submucosal tissues, affecting respiratory or gastrointestinal tracts.

Purpose of the Study:

To outline the role of emergency physicians in managing hereditary angioedema.
To emphasize the importance of understanding HAE pathophysiology for effective treatment.

Main Methods:

Review of HAE pathophysiology and clinical presentation.
Discussion of diagnostic limitations during acute attacks.
Emphasis on airway assessment as the primary step in emergency management.

Main Results:

Laboratory studies and imaging have limited utility in acute HAE attacks unless diagnosis is uncertain.
Airway assessment is critical to determine the need for immediate intervention.
Understanding HAE pathophysiology guides emergency management decisions.

Conclusions:

Emergency physicians require knowledge of HAE pathophysiology.
Prompt airway evaluation is paramount in managing acute HAE attacks.
Effective management relies on understanding the underlying genetic disorder and its clinical manifestations.