Related Experiment Video
Updated: Jul 2, 2026
09:33
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
28.5K
Micro-structural white matter abnormalities in new daily persistent headache: a DTI study using TBSS analysis.
Yanliang Mei1, Wei Wang1, Dong Qiu1
1Headache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
The Journal of Headache and Pain
|July 2, 2023
Summary
New daily persistent headache (NDPH) is linked to widespread brain white matter abnormalities. This study used MRI to find differences in white matter structure in NDPH patients compared to healthy individuals.
Area of Science:
- Neurology
- Neuroimaging
- Neuroscience
Background:
- New daily persistent headache (NDPH) is a rare primary headache disorder.
- Characterized by sudden onset, daily, and persistent headaches.
- The underlying causes and white matter changes in NDPH are not well understood.
Purpose of the Study:
- To investigate micro-structural white matter abnormalities in NDPH patients.
- To gain insights into the pathogenesis of NDPH using tract-based spatial statistics (TBSS).
Main Methods:
- Included 21 NDPH patients and 25 healthy controls (HCs).
- Acquired T1 structural and diffusion magnetic resonance imaging (MRI).
- Analyzed fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) using TBSS.
Main Results:
- NDPH patients showed significantly decreased FA and increased MD and RD compared to HCs.
- Abnormalities were observed in 16 major white matter tracts, including the corpus callosum, cingulum, and corticospinal tract.
- No significant correlations were found between diffusion parameters and clinical features of NDPH.
Conclusions:
- Patients with NDPH exhibit widespread white matter abnormalities.
- These findings suggest a potential role for white matter changes in NDPH pathogenesis.
