Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Terminating a long-term clinical trial.

C R Klimt, P L Canner

    Clinical Pharmacology and Therapeutics
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Managing clinical trial terminations is crucial. This study explores various reasons for ending long-term trials, including ineffectiveness, patient subgroup exclusion, and therapeutic breakthroughs, offering insights into successful strategies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of niacin on the incidence of new onset diabetes and cardiovascular events in patients with normoglycaemia and impaired fasting glucose.

    International journal of clinical practice·2013
    Same author

    Early risks of hormone therapy in patients with coronary heart disease.

    JAMA·2000
    Same author

    An application of the Zucker-Wittes modified ratio estimate statistic in the Post Coronary Artery Bypass Graft (CABG) clinical trial.

    Controlled clinical trials·1997
    Same author

    Deaths from injury, violence, and suicide in secondary prevention trials of cholesterol lowering.

    The New England journal of medicine·1991
    Same author

    Emergency department duty: a training model for the future.

    Military medicine·1991
    Same author

    The Hypertension Prevention Trial: assessment of the quality of blood pressure measurements.

    American journal of epidemiology·1991
    Same journal

    Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Symposium Report: Stakeholders' Perspectives on Phase 1 Trials in Japanese Prior to Multi-Regional Clinical Trials and Future Pathways.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Risk of Hyperkalemia in Patients with Heart Failure Treated with Spironolactone in Combination with Sacubitril/Valsartan vs. Renin-Angiotensin System Inhibitors.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Composite Endpoints in Contemporary Cardiovascular Trials: Trends in Phase 3 Trials and Key Issues in Regulatory Review.

    Clinical pharmacology and therapeutics·2026
    See all related articles

    Area of Science:

    • Clinical Trials
    • Medical Research Methodology
    • Drug Development

    Background:

    • Long-term clinical trials frequently involve multiple active treatment arms.
    • Independent discontinuation of treatment groups is common due to efficacy or safety concerns.
    • Patient subgroups may be excluded during trials if they respond inadequately.

    Purpose of the Study:

    • To analyze diverse termination scenarios in long-term clinical trials.
    • To present practical examples of managing trial terminations.
    • To evaluate successful and unsuccessful termination management techniques.

    Main Methods:

    • Review of termination events in long-term clinical trials.
    • Case study analysis of author experiences.

    Related Experiment Videos

  • Qualitative assessment of management strategies.

    • Main Results:

    • Trials can terminate due to lack of efficacy, patient exclusion, therapeutic breakthroughs, or abandonment of hope.
    • Successful and unsuccessful management techniques for various termination types were observed.
    • Author experiences highlight practical challenges and solutions in trial termination.

    Conclusions:

    • Effective management of clinical trial terminations is essential for research integrity.
    • Understanding diverse termination reasons informs better trial design and execution.
    • Strategies for managing trial endings, whether planned or unplanned, are critical for advancing medical knowledge.