A new assessment method for right ventricular diastolic function using right heart catheterization by pressure-volume...

Area of Science:

• Cardiology
• Physiology

Background:

• Diastolic stiffness coefficient (β) and end-diastolic elastance (Eed) are key ventricular diastolic parameters.
• Assessing right ventricular diastolic function is challenging due to a lack of established methods.

Purpose of the Study:

• To evaluate the validity of calculating β and Eed using only right heart catheterization (RHC) data.
• To assess this method in patients with restrictive cardiomyopathy (RCM) and cardiac amyloidosis.

Main Methods:

• Retrospective analysis of 46 heart failure patients undergoing RHC and cardiac magnetic resonance (CMR).
• Calculation of right ventricular end-diastolic and end-systolic volumes using RHC data.
• Comparison of RHC-derived β and Eed with CMR-derived values and echocardiography.

Main Results:

• RHC-derived ventricular volumes strongly correlated with CMR findings.
• RHC-calculated β and Eed showed significant correlation with conventional CMR methods.
• Higher β and Eed values were observed in RCM with amyloidosis compared to dilated cardiomyopathy.
• RHC-derived β and Eed correlated well with the echocardiographic E/A ratio.

Conclusions:

• An accessible method using RHC data was established to estimate right ventricular β and Eed.
• This method effectively demonstrates right ventricular diastolic dysfunction in RCM and amyloidosis patients.