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Targeting the Tumor-Tumor Microenvironment Crosstalk.
Sunil S Badve1, Yesim Gökmen-Polar1
1Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
Expert Opinion on Therapeutic Targets
|July 3, 2023
Summary
Targeting both cancer cells and their microenvironment (TME) offers a promising strategy to overcome treatment resistance. Co-targeting tumor-TME interactions can improve cancer control and clinical outcomes.
Area of Science:
- Oncology
- Cancer Biology
- Immunology
Background:
- Cancer development involves complex co-evolution of cancer cells and their microenvironment (TME).
- Traditional therapies primarily target cancer cells, often overlooking crucial T-TME interactions.
- Tumor-TME cross-talk and heterogeneity contribute significantly to treatment resistance.
Conclusions:
- Dual targeting of tumor and TME holds promise for enhancing cancer control.
- Considering tissue context and tumor type is vital for optimizing therapeutic strategies.
- Further research into T-TME interactions can lead to improved clinical outcomes.
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