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Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Related Experiment Video

Updated: Jul 24, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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Anorectal melanoma.

Suzanne Fastner1, Tina J Hieken2, Robert R McWilliams3

  • 1Huntsman Cancer Institute, Salt Lake City, Utah, USA.

Journal of Surgical Oncology
|July 3, 2023
PubMed
Summary
This summary is machine-generated.

Anorectal melanoma, a rare and aggressive cancer, requires tailored treatment. This review details its unique characteristics, staging, surgery, and therapies compared to skin melanoma.

Keywords:
adjuvantanorectal melanomaimmunotherapylocal excisionmelanomamucosal melanomaproctectomyradiotherapy

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Area of Science:

  • Oncology
  • Dermatology
  • Gastroenterology

Background:

  • Anorectal melanoma is an aggressive mucosal melanoma subtype.
  • It has a poor prognosis compared to cutaneous melanoma.
  • Optimal treatment strategies are still evolving.

Purpose of the Study:

  • To review the pathogenesis of anorectal melanoma.
  • To discuss new staging concepts for mucosal melanoma.
  • To update on surgical management, radiation, and systemic therapy.

Main Methods:

  • Literature review of anorectal melanoma.
  • Comparison of mucosal versus cutaneous melanoma.
  • Analysis of current treatment data.

Main Results:

  • Highlights differences in pathogenesis between mucosal and cutaneous melanoma.
  • Discusses novel staging systems for mucosal melanoma.
  • Reviews updated surgical approaches and adjuvant therapies.

Conclusions:

  • Anorectal melanoma management requires specialized approaches.
  • Understanding its unique features is crucial for treatment.
  • Further research is needed to optimize therapy for this patient population.