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Updated: Jul 24, 2025

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
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Fibrinolytic drugs induced hemorrhage: mechanisms and solutions

Mingqing Tang1, Chengjia Hu, Hongjun Lin

  • 1Medicine School, Huaqiao University, Quanzhou, Fujian, China.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|July 3, 2023
PubMed

Thrombosis has been emerging as a major global life-threatening issue with high mortality and serious complications, especially in the post-COVID-19 era. Compared with the commonly used plasminogen activators thrombolytic drugs, fibrinolytic drugs are no longer heavily dependent on the patients' own plasminogen, which are poorly expressed in most patients. As a novel "direct acting" thrombolytic agent, fibrinolytic drugs are considered to have stronger thrombolytic efficacy and safety than the widely used plasminogen activators. However, the risk of their hemorrhage remains a major concern. Herein, the molecular mechanisms and solutions were summarized for the first time based on the systematic review of the latest developments, which could shed new light on the development of novel safety fibrinolytic drugs in the future.

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