Jove
Visualize
Contact Us

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

43
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
43
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.

Molecular genetics and genomics : MGG·2026
Same author

Multiancestral GWAS of Dental Malocclusion Identifies Multiple Risk Loci.

Journal of dental research·2026
Same author

Epigenetic Signatures in Monozygotic and Dizygotic Twins Discordant for Orofacial Clefts.

medRxiv : the preprint server for health sciences·2026
Same author

Oral microbiome diversity, community- and taxon-level differences by oral human papillomavirus (HPV) and race/ethnicity.

Infectious agents and cancer·2026
Same author

Clinical Predictors of Nose/throat Bacteriome and Fungal Colonization in Skilled Nursing Facility Residents.

The Journal of infectious diseases·2026
Same author

Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci.

medRxiv : the preprint server for health sciences·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 24, 2025

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
10:24

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

11.7K

Bacterial Community Modifies Host Genetics Effect on Early Childhood Caries.

F Blostein1, T Zou2, D Bhaumik1

  • 1Department of Epidemiology, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Journal of Dental Research
|July 3, 2023
PubMed
Summary

The oral microbiome significantly influences early childhood caries (ECC) risk, interacting with genetic susceptibility. Identifying and preventing cariogenic oral microbiomes offers a universal benefit for reducing ECC incidence.

Keywords:
dental cariesepidemiologygenomicsmicrobiomepediatricssaliva

More Related Videos

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
10:42

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

17.2K
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

6.4K

Related Experiment Videos

Last Updated: Jul 24, 2025

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
10:24

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

11.7K
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
10:42

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

17.2K
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

6.4K

Area of Science:

  • Oral Health
  • Microbiology
  • Genetics

Background:

  • Early childhood caries (ECC) affects approximately 20% of children by age 5.
  • Both oral microbiome and host genetics are implicated in ECC susceptibility.
  • The interplay between the oral microbiome and genetic predisposition to ECC remains largely unexplored.

Purpose of the Study:

  • To investigate whether the salivary bacteriome modifies the association between genetic susceptibility (polygenic score) and ECC in a longitudinal birth cohort.
  • To determine the independent and interactive effects of genetic risk and salivary bacterial community state types (CSTs) on ECC development.

Main Methods:

  • A polygenic score (PGS) for primary tooth decay was constructed using genome-wide association data.
  • Poisson regression was used to assess the association between PGS and ECC incidence.
  • Salivary bacteriome data (24 months) and ECC status (60 months) were analyzed for effect modification by bacterial community state types (CSTs).

Main Results:

  • A high PGS was not significantly associated with increased ECC incidence.
  • Cariogenic salivary bacterial CSTs at 24 months were strongly associated with ECC by 60 months (OR, 7.48).
  • A significant interaction (P=0.04) was observed between salivary bacterial CST and PGS, where PGS was associated with ECC only in children with non-cariogenic CSTs.

Conclusions:

  • The oral microbiome plays a critical role in modifying genetic susceptibility to ECC.
  • Genetic risk for ECC may be masked or amplified by the oral microbiome composition.
  • Targeting and preventing colonization by cariogenic oral microbiomes could be a universally beneficial strategy for ECC prevention across varying genetic risk profiles.