Related Experiment Video
Updated: Jul 24, 2025
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
Published on: September 12, 2014
Amniotic Membrane Transplantation for Reconstruction of Ocular Surface Lesion Excisions in Pediatric Population
Okyanus Bulut1, Melis Palamar, Banu Yaman
1Departments of Ophthalmology (O.B., M.P., S.E., A.Y., O.B.S.), and Pathology (B.Y.), Ege University, Izmir, Turkey.
Insights
Human amniotic membrane transplantation (hAMT) is safe and effective for pediatric ocular surface reconstruction after lesion removal. This study reviewed 31 pediatric cases, confirming hAMT
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Pediatric Surgery
Background:
- The ocular surface requires specialized regenerative materials for reconstruction.
- Human amniotic membrane (hAMT) possesses anti-inflammatory, antimicrobial, and wound-healing properties.
- Limited data exists on hAMT efficacy specifically in pediatric populations.
Purpose of the Study:
- To evaluate the application of human amniotic membrane transplantation (hAMT) for ocular surface reconstruction in pediatric patients.
- To define the clinical use and outcomes of hAMT following ocular surface lesion excisions in children.
- To assess the safety and effectiveness of hAMT in a pediatric cohort over a ten-year period.
Main Methods:
- Retrospective analysis of 31 pediatric patients undergoing hAMT between 2009 and 2021.
- Inclusion criteria: ocular surface lesion excision followed by hAMT.
- Data collected included patient demographics, procedure details, and amniotic membrane degradation time.
Main Results:
- The study included 31 patients (14 female, 17 male) with a mean age of 10.1 years.
- The majority of patients (94.4%) received a single hAMT procedure.
- The mean duration of amniotic membrane degradation was 21.5 days.
Conclusions:
- Human amniotic membrane transplantation (hAMT) appears to be a safe and effective option for ocular surface reconstruction in pediatric patients.
- The findings support the use of hAMT for managing ocular surface defects in children.
- Further research can explore long-term outcomes and specific indications for hAMT in pediatric ophthalmology.
Purpose:
To define the use of human amniotic membrane transplantation (hAMT) for reconstruction of the ocular surface after ocular surface lesion excisions in pediatric population during the last decade in a tertiary eye center.
Methods:
A total of 31 patients who underwent hAMT procedure because of the excision of ocular surface lesions between January 2009 and December 2021 were included in this study. The medical data were retrospectively evaluated.
Results:
The female-to-male ratio was 14/17. The mean age of the patients was 10.1±4.1 (range, 1-18) years. Although a single hAMT was applied to most of the cases (94.4%; 34 eyes), more than one hAMT was applied to 5.6% of cases (2 eyes). The amniotic membrane degradation duration was found to be 21.5±10.8 (range, 13-50) days.
Conclusions:
Amniotic membrane is used as a biomaterial in various ocular surface diseases with its anti-inflammatory, antimicrobial, and wound healing properties. Although widely used, there are only a few studies reporting its clinical efficacy in the pediatric age group. It seems to be safe and effective in pediatric age group for ocular surface reconstruction after ocular surface lesion excisions.
More Related Videos
11:20Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
10:24Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018