Related Experiment Video

Updated: Jul 24, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Immunotherapy combinations for metastatic castration-resistant prostate cancer - failed trials and future aspects

Susan F Slovin1

  • 1Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Current Opinion in Urology
|July 3, 2023
PubMed
Abstract

Insights

Prostate cancer immunotherapy using checkpoint inhibitors has failed to improve survival. Novel strategies targeting unique cancer antigens, including vaccines and CAR T-cells, show promise for future treatments.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Therapeutics

Background:

  • Prostate cancer immunotherapy, particularly immune checkpoint blockade, has not demonstrated significant survival benefits in clinical trials.
  • Despite extensive research, combination therapies involving checkpoint inhibitors have failed to meet primary endpoints for overall survival (OS) and radiographic progression-free survival (rPFS).

Approach:

  • Exploring novel immunotherapeutic strategies targeting unique cell surface antigens expressed across various cancer types.
  • Investigating advanced modalities such as cancer vaccines, chimeric antigen receptor (CAR) T-cell therapy, bispecific T-cell engagers, and antibody-drug conjugates.

Key Points:

  • Newer immunologic strategies are focusing on specific tumor antigens that are pan-carcinoma, offering potential therapeutic targets.
  • These novel approaches aim to overcome the limitations of current checkpoint inhibitor therapies in prostate cancer.

Conclusions:

  • While checkpoint inhibitors have shown limited success, continued research into targeted immunotherapies is crucial for advancing prostate cancer treatment.
  • Developing therapies directed at unique tumor antigens represents a promising avenue for improving patient outcomes in prostate cancer.

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