Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intellectual impairment after hyperthyroidism.

H Perrild, J M Hansen, K Arnung

    Acta Endocrinologica
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reactive oxygen species alter dopaminergic and purinergic signaling and microglia physiology in the nucleus accumbens.

    bioRxiv : the preprint server for biology·2026
    Same author

    The association between migraine and dementia - a national register-based matched cohort study.

    Public health·2022
    Same author

    Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    More precise phenotyping of cluster headache using prospective attack reports.

    European journal of neurology·2019
    Same author

    Identification of New Sources of Resistance in Winter Wheat to Multiple Strains of Xanthomonas translucens pv. undulosa.

    Plant disease·2019
    Same author

    The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
    Same journal

    Iodine deficiency in Ukraine.

    Acta endocrinologica·1993
    Same journal

    Plasma glucagon responses to insulin-induced hypoglycemia and arginine in spontaneous non-insulin-dependent diabetes mellitus (NIDDM) rats, Otsuka Long Evans Tokushima Fatty (OLETF) strain.

    Acta endocrinologica·1993
    Same journal

    Comparison between the human serum growth hormone-binding protein and the water-soluble growth hormone-binding site released from IM-9 lymphocytes.

    Acta endocrinologica·1993
    Same journal

    Prolactin stimulates [3H]dopamine release from dispersed rat tubero-infundibular dopaminergic neurons and dopamine decreases gonadotropin-releasing hormone release induced by calcium ionophore.

    Acta endocrinologica·1993
    Same journal

    Effects of long-term estradiol exposure on the hypothalamic neuron number.

    Acta endocrinologica·1993
    Same journal

    Aromatase activity in the mare ovary during estrous cycle. Measurement of endogenous steroids and of their in vitro inhibitory effect.

    Acta endocrinologica·1993
    See all related articles

    Long-term hyperthyroidism treatment may not fully reverse brain damage. Many patients show persistent EEG abnormalities and cognitive deficits years after recovery, indicating potential irreversible effects.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Neurology

    Background:

    • Hyperthyroidism, a condition of excess thyroid hormone, can impact brain function.
    • Previous research suggests potential neurological consequences of thyrotoxicosis.
    • The long-term effects of hyperthyroidism on cognitive function require further investigation.

    Purpose of the Study:

    • To assess long-term neurological and neuropsychological sequelae in patients successfully treated for hyperthyroidism.
    • To compare brain function in formerly hyperthyroid patients with a control group.
    • To determine the prevalence of persistent intellectual impairment after hyperthyroidism.

    Main Methods:

    • Electroencephalography (EEG) and eleven neuropsychological tests were administered.

    Related Experiment Videos

  • The study included 26 patients 10 years post-hyperthyroidism treatment and a control group.
  • Statistical analysis compared EEG abnormalities and neuropsychological test results between groups.

    • Main Results:

    • 68% of formerly hyperthyroid patients exhibited abnormal EEG 10 years post-treatment, versus 41% in controls (P<0.05).
    • Significant cognitive impairments were observed in formerly hyperthyroid patients across multiple neuropsychological tests.
    • 23% of patients showed marked to severe intellectual impairment, compared to 0% in controls (P<0.05).

    Conclusions:

    • Successful hyperthyroidism treatment does not always restore normal brain function.
    • Persistent EEG abnormalities and intellectual deficits suggest potentially irreversible brain dysfunction.
    • Intellectual impairment following thyrotoxicosis is a frequent, under-recognized clinical finding.