Comparative multiple threshold analysis: a possible new way for validating schizophrenia classifications

Activ. nerv. sup. (Praha) 28, 2. 1986. 350 carefully selected schizophrenic probands and their parents and siblings were diagnosed according to three different clinical classifications and a multiple-threshold analysis was carried out within the framework of the multifactorial model of inheritance. The results suggest that of the three classificatory systems studied, Leonard's and Sneshnevsky's nosological system delineate relatively homogeneous subtypes from the clinical and genetic point of view, pointing to the promise these nosological systems have for the planning of future research in psychiatric genetics.