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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Relationship Between Serum ET-1, HDL-C, and sVCAM-1 and Hearing Loss in Patients with Sudden Deafness
1Shanxi Medical University, Taiyuan City, 030001, Shanxi Province, China.
Insights
Vascular factors like endothelin-1 (ET-1), HDL-C, and sVCAM-1 are linked to sudden sensorineural hearing loss (SSHL). Elevated ET-1 and sVCAM-1, with lower HDL-C, indicate poorer outcomes and aid in diagnosis.
Area of Science:
- Otolaryngology
- Vascular Biology
- Biochemistry
Background:
- Sudden sensorineural hearing loss (SSHL) is often linked to vascular issues.
- Understanding the role of specific vascular markers in SSHL is crucial for diagnosis and prognosis.
Purpose of the Study:
- To investigate the relationship between serum endothelin-1 (ET-1), high-density lipoprotein cholesterol (HDL-C), and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and the severity of hearing loss in SSHL patients.
- To evaluate the diagnostic and prognostic value of these biomarkers in SSHL.
Main Methods:
- Serum levels of ET-1, HDL-C, and sVCAM-1 were measured using enzyme-linked immunosorbent assay (ELISA) in 60 SSHL patients and 60 healthy controls.
- Statistical analysis and Receiver Operating Characteristic (ROC) curve analysis were employed to assess relationships and diagnostic accuracy.
Main Results:
- SSHL patients exhibited increased serum ET-1 and sVCAM-1 levels, and decreased HDL-C levels compared to controls.
- Higher ET-1 and sVCAM-1, and lower HDL-C, were observed in patients aged ≥45 years and those with severe hearing loss.
- ROC analysis confirmed excellent diagnostic values for ET-1 (AUC=0.839), HDL-C (AUC=0.830), and sVCAM-1 (AUC=0.865).
- Low ET-1 and sVCAM-1, with high HDL-C, correlated with better hearing prognosis.
Conclusions:
- Abnormal serum levels of ET-1, HDL-C, and sVCAM-1 are significantly associated with age and hearing loss severity in SSHL.
- These biomarkers possess notable diagnostic and prognostic capabilities for SSHL.
Abstract:
Vascular causes are most commonly associated with sudden sensorineural hearing loss (SSHL). This study was performed to determine the relationship between serum endothelin-1 (ET-1), high-density lipoprotein cholesterol (HDL-C), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels, and the degree of hearing loss in patients with SSHL. Firstly, 60 SSHL patients were admitted to The First Hospital of Shanxi Medical University. In the same period, 60 healthy subjects matching the age and gender of SSHL patients were selected as the control group. Then, serum levels of ET-1, HDL-C, and sVCAM-1 were measured by enzyme-linked immunosorbent assay (ELISA). Next, the relationship between serum levels of ET-1, HDL-C, and sVCAM-1 with clinicopathological factors and their diagnostic and prognostic values were analyzed and evaluated. Serum ET-1 and sVCAM-1 were increased, and HDL-C was decreased in patients with SSHL. Serum ET-1 and sVCAM-1 were higher and HDL-C was lower in patients aged ≥ 45 years, or severe hearing loss patients (P < 0.05). ROC analysis determined that ET-1 (AUC = 0.839), HDL-C (AUC = 0.830), and sVCAM-1 (AUC = 0.865) had excellent diagnostic values. In addition, patients with low levels of ET-1 and sVCAM-1 and high levels of HDL-C had better hearing prognosis (P < 0.05). Abnormal serum ET-1, HDL-C, and sVCAM-1 in patients with SSHL are closely related to age, and degree of hearing loss, and perform diagnostic and prognostic values.
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