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Targeted Cancer Therapies

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Recalcitrant Cutaneous Mastocytosis Treated With Genetically Informed Targeted Therapy: A Case Report.

Laura Gleason¹, Volkan Tekmen¹, Alexa Cohen¹

¹Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

International Journal of Dermatology and Venereology

|July 3, 2023

Summary

This summary is machine-generated.

Mastocytosis treatment can now be guided by genetic analysis of skin mast cells. This approach successfully treated a patient with refractory cutaneous mastocytosis using targeted therapy.

Area of Science:

Dermatology
Oncology
Genetics

Background:

Mastocytosis involves mast cell proliferation, presenting as cutaneous or systemic disease.

Keywords:

c-KIT mastocytosis midostaurin molecular genetics targeted therapy

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Systemic mastocytosis is treated with targeted therapy for the c-KIT mutation.

Guidelines for refractory cutaneous mastocytosis are lacking.