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Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
363
Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Related Experiment Video

Updated: Jul 24, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multiple Myeloma (Part 2) - Update on The Approach to Bone Disease.

Alex Guedes1, Ricardo Gehrke Becker2, Luiz Eduardo Moreira Teixeira3

  • 1Grupo de Oncologia Ortopédica, Hospital Santa Izabel, Santa Casa de Misericórdia da Bahia, Salvador, BA, Brasil.

Revista Brasileira De Ortopedia
|July 3, 2023
PubMed
Summary

Multiple myeloma (MM) bone disease (MMBD) is increasingly common in aging populations. Early diagnosis and a multidisciplinary approach involving medication, radiation, and surgery are crucial for managing bone lesions and improving patient quality of life.

Keywords:
DiphosphonatesFractures SpontaneousMultiple myelomaOrthopedic proceduresProphylactic Surgical proceduresRadiotherapy.

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Area of Science:

  • Oncology
  • Orthopedics
  • Geriatrics

Background:

  • Global life expectancy increases have led to a higher prevalence of multiple myeloma (MM), a cancer predominantly affecting older adults.
  • Bone lesions are a common and significant complication in MM patients, necessitating timely and comprehensive management strategies.
  • Multiple myeloma bone disease (MMBD) impacts patient mobility, pain levels, and overall quality of life, underscoring the need for effective interventions.

Purpose of the Study:

  • To provide an updated review of multiple myeloma bone disease (MMBD).
  • To cover key aspects including pathophysiology, clinical presentation, diagnostic methods, and therapeutic interventions for MMBD.
  • To equip healthcare professionals with current knowledge for managing MMBD.

Main Methods:

  • Literature review focusing on recent advancements in understanding and treating MMBD.
  • Synthesis of information on pathophysiology, clinical and laboratory findings, imaging techniques, differential diagnoses, and treatment modalities.
  • Compilation of data from relevant scientific publications and clinical guidelines.

Main Results:

  • MMBD management requires a multidisciplinary approach, integrating medical treatments, radiotherapy, and orthopedic surgery.
  • Surgical interventions aim to prevent fractures, stabilize existing lesions, decompress the spinal cord, and restore function.
  • Effective management of MMBD can lead to pain relief, improved ambulation, and enhanced patient quality of life.

Conclusions:

  • MMBD is a critical complication of multiple myeloma that demands proactive and integrated care.
  • A thorough understanding of MMBD's pathophysiology and clinical manifestations is essential for optimal patient outcomes.
  • The review highlights the importance of early intervention and a tailored therapeutic strategy for MMBD patients.