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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
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Management of primary cardiac leiomyosarcoma
Lucrecia Aline Cabral Formigosa1,2, Luciana Ferreira Dos Santos1, Jaqueline Dantas Neres Martins1
1Population Based Cancer Registry of Belém, Belém 66093-677, Brazil.
Ecancermedicalscience
|July 3, 2023
Summary
Primary cardiac leiomyosarcoma is rare, presenting with varied symptoms. This case highlights successful surgical resection, radiotherapy, and chemotherapy, leading to a 5-year disease-free survival for a left atrial tumor.
Area of Science:
- Cardiovascular Medicine
- Oncology
- Surgical Pathology
Background:
- Primary cardiac tumors are exceptionally rare, often presenting with nonspecific symptoms or leading to sudden death.
- Leiomyosarcoma, a malignant mesenchymal tumor, can rarely originate in the heart, posing diagnostic and therapeutic challenges.
Observation:
- A 33-year-old female presented with dyspnea, syncope, and hemoptysis, symptoms mimicking other cardiac conditions.
- Transthoracic echocardiography revealed a left atrial mass causing mitral stenosis and mild valvular insufficiencies.
Findings:
- Complete surgical resection (R0) of the left atrial leiomyosarcoma was achieved.
- Adjuvant therapy included 25 radiotherapy sessions and 5 cycles of gemcitabine and docetaxel chemotherapy.
- The patient remained disease-free with no recurrence or metastasis at 5-year follow-up.
Implications:
- This case underscores the importance of considering rare cardiac malignancies in patients with unexplained cardiac symptoms.
- Multimodal treatment involving surgery, radiotherapy, and chemotherapy can achieve long-term remission for primary cardiac leiomyosarcoma.
- Early diagnosis and comprehensive management are crucial for improving outcomes in primary cardiac tumors.
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