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AXL/Gas6 signaling mechanisms in the hypothalamic-pituitary-gonadal axis

Pardis Mohammadzadeh1, Gregory C Amberg1

  • 1Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Frontiers in Endocrinology
|July 3, 2023
PubMed

Insights

AXL receptor tyrosine kinase and its ligand Gas6 regulate neuroendocrine development and function. This signaling pathway impacts the brain, pituitary, and gonads, influencing reproductive health and disease.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Neuroscience

Background:

  • AXL receptor tyrosine kinase is linked to various cancers.
  • AXL and its ligand Gas6 are crucial for neuroendocrine system development and function.
  • AXL signaling affects neuroendocrine systems in the brain, pituitary, and gonads.

Purpose of the Study:

  • To review AXL/Gas6 signaling mechanisms.
  • To focus on molecular pathways in neuroendocrine function, health, and disease.
  • To identify knowledge gaps and guide future research.

Main Methods:

  • Literature review of AXL/Gas6 signaling.
  • Focus on molecular pathways in neuroendocrine function.
  • Analysis of AXL's role in development and disease.

Main Results:

  • AXL signaling impacts neuroendocrine structure and function.
  • AXL inhibits gonadotropin-releasing hormone (GnRH) production during development.
  • AXL is vital for GnRH neuron migration and spermatogenesis.

Conclusions:

  • AXL/Gas6 signaling is a key regulator of the neuroendocrine system.
  • Dysregulation of AXL/Gas6 is implicated in reproductive diseases like idiopathic hypogonadotropic hypogonadism.
  • Further research into AXL/Gas6 pathways is needed to understand its full role in health and disease.
Keywords:
TAM receptor tyrosine kinaseanterior pituitarygonadshypothalamussignaling/signaling pathways

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