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Growth Differentiation Factor-15 and Clinical Outcomes in Japanese Patients With Ischemic Heart Disease

Yuta Kobayashi1, Yoichiro Otaki1, Tetsu Watanabe1

  • 1Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.

JACC. Asia
|July 3, 2023
PubMed

Insights

Growth Differentiation Factor (GDF)-15 is a predictor of adverse outcomes in Japanese patients with ischemic heart disease (IHD). Elevated GDF-15 levels correlate with increased mortality, major adverse cardiovascular events, and bleeding risk.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Outcomes

Background:

  • Ischemic heart disease (IHD) presents significant mortality and bleeding risks in Asian populations.
  • Growth Differentiation Factor (GDF)-15, a stress cytokine, is linked to poor outcomes in Western IHD patients.
  • The role of GDF-15 in Asian IHD patients remains unclear.

Purpose of the Study:

  • To investigate the association between serum GDF-15 levels and clinical outcomes in Japanese patients with IHD.

Main Methods:

  • Serum GDF-15 levels were measured in 632 IHD patients.
  • Patients were followed for a median of 2.8 years.
  • Primary endpoint: all-cause mortality; Secondary endpoints: MACE, HF rehospitalization, bleeding, and thrombotic events.

Main Results:

  • Elevated GDF-15 was observed in acute coronary syndrome, severe CAD, and high bleeding risk.
  • GDF-15 independently predicted mortality, MACE, HF rehospitalization, and bleeding, but not thrombotic events.
  • GDF-15 improved risk prediction for mortality, MACE, HF, and bleeding.

Conclusions:

  • Serum GDF-15 is a potential marker for major bleeding and adverse clinical outcomes in Japanese IHD patients.
Abstract

Keywords:
GDF-15clinical outcomeshigh bleeding riskischemic heart disease

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