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Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes
Min Chen1,2, Jie-Ying Zhu1,2, Wang-Jing Mu1,2
1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Genes & Diseases
|July 3, 2023
Summary
Cysteine dioxygenase type 1 (CDO1) is a key enzyme in cysteine metabolism, impacting various physiological and pathological processes. Understanding CDO1 mechanisms offers insights into potential therapeutic strategies and risks.
Area of Science:
- Biochemistry
- Enzymology
- Molecular Biology
Background:
- Cysteine dioxygenase type 1 (CDO1) is a mammalian non-heme Fe(II) dioxygenase crucial for cysteine catabolism.
- CDO1 regulates diverse physiological processes, including lipid metabolism, adipogenesis, redox homeostasis, and organismal development.
Purpose of the Study:
- To elucidate the multifaceted roles of CDO1 in physiological and pathophysiological contexts.
- To explore the therapeutic potential and risks associated with targeting CDO1.
Main Methods:
- Review and synthesis of existing literature on CDO1 function and regulation.
- Analysis of CDO1's involvement in metabolic pathways and disease progression.
Main Results:
- CDO1 activity is tightly regulated and influences numerous biological functions through cysteine metabolism.
- Aberrant CDO1 expression and promoter methylation correlate with tumor progression and malignancy.
- CDO1 overexpression can induce ferroptosis in cancer cells and may ameliorate metabolic and neurodegenerative disorders.
Conclusions:
- CDO1 plays a critical role in both normal physiology and disease states, particularly in cancer and metabolic disorders.
- Targeting CDO1 presents therapeutic opportunities for metabolic and neurodegenerative diseases and cancer treatment.
- Further research into CDO1 mechanisms is essential for evaluating its therapeutic potential and associated risks.
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