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Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical

Marcel Silva Luz1, Fabian Fellipe Bueno Lemos1, Samuel Luca Rocha Pinheiro1

  • 1Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil.

World Journal of Virology
|July 3, 2023
PubMed

Insights

Multisystemic inflammatory syndrome in children (MIS-C) is a severe condition linked to SARS-CoV-2. This review explores MIS-C

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Public health

Background:

  • The COVID-19 pandemic has presented unique challenges in pediatric populations.
  • Multisystemic inflammatory syndrome in children (MIS-C) emerged as a severe complication of SARS-CoV-2 infection in youth.
  • MIS-C involves hyperinflammation and multiorgan dysfunction, distinct from typical pediatric COVID-19 presentations.

Purpose of the Study:

  • To synthesize current evidence on the pathogenesis, clinical features, and management of MIS-C.
  • To provide insights for clinical practice and guide future research directions.
  • To address the lack of definitive management guidelines for this pediatric condition.

Main Methods:

  • Comprehensive literature review of studies on MIS-C.
  • Analysis of pathogenic mechanisms, clinical manifestations, and treatment strategies.
  • Synthesis of evidence to inform clinical decision-making.

Main Results:

  • MIS-C is characterized by a severe hyperinflammatory response and multiorgan involvement in children and adolescents.
  • Pathogenesis appears linked to immune dysregulation following SARS-CoV-2 infection.
  • Current management strategies are evolving due to the condition's complexity and lack of established guidelines.

Conclusions:

  • Understanding MIS-C's pathogenesis is crucial for developing effective treatments.
  • Standardized diagnostic criteria and management protocols are needed.
  • Further research is essential to elucidate immune dysregulation and optimize patient outcomes.

Keywords:
COVID-19COVID-19 relatedDisease managementEtiologyMultisystem inflammatory syndrome in childrenPediatric multisystem inflammatory diseaseSARS-CoV-2

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