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Etiopathogenic theories about long COVID
1Department of Internal Medicine, Virology, Research, Study Group for the Diagnosis and Treatment of COVID-19 in Veracruz, Veracruz 91900, Veracruz, Mexico. neurona23@hotmail.com.
World Journal of Virology
|July 3, 2023
Summary
Long COVID
Area of Science:
- Immunology
- Virology
- Pathophysiology
Background:
- Long coronavirus disease (COVID) presents a complex clinical challenge with unclear etiopathogenic mechanisms.
- Existing research explores various theories, including viral persistence, autoimmunity, and microbiome dysbiosis.
Purpose of the Study:
- To comprehensively review and synthesize the primary etiopathogenic theories of long COVID.
- To elucidate the underlying pathophysiology by integrating these theories.
- To discuss current real-world treatment strategies for long COVID.
Main Methods:
- Literature review and synthesis of current scientific understanding of long COVID.
- Analysis of proposed etiopathogenic mechanisms.
- Discussion of clinical treatment options.
Main Results:
- Multiple interconnected theories contribute to the complex pathophysiology of long COVID.
- Current treatments include antiviral medications (Paxlovid), antibiotics for dysbiosis, anticoagulation, and immunomodulatory agents (temelimab).
Conclusions:
- Understanding the multifactorial pathophysiology of long COVID is crucial for effective treatment.
- A combination of therapeutic approaches targeting different proposed mechanisms may be necessary.
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