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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Impacts of SARS-CoV-2 on diabetes mellitus: A pre and post pandemic evaluation

A H M Nurun Nabi1, Akio Ebihara2, Hossain Uddin Shekhar3

  • 1Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh.

World Journal of Virology
|July 3, 2023
PubMed

Insights

The COVID-19 pandemic, caused by SARS-CoV-2, significantly impacts individuals with diabetes. This review explores coronavirus origins, COVID-19

Area of Science:

  • Virology
  • Immunology
  • Genetics

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has led to widespread morbidity and mortality.
  • COVID-19 severity is influenced by viral strain, host genetics, environment, and comorbidities such as diabetes.
  • Diabetes, characterized by hyperglycemia, increases susceptibility to infections and exacerbates COVID-19 outcomes.

Purpose of the Study:

  • To review the origins of coronaviruses and SARS-CoV-2.
  • To examine the impact of SARS-CoV-2 infection on individuals with diabetes.
  • To discuss the role of host genetics in COVID-19 pathogenesis.

Main Methods:

  • Literature review of studies on coronavirus origins.
  • Analysis of research on COVID-19 in diabetic populations.
  • Examination of genetic factors influencing disease severity.

Main Results:

  • SARS-CoV-2 infection can cause beta-cell damage and cytokine storms in diabetic patients.
  • These effects lead to hyperglycemia and insulin resistance, worsening COVID-19 severity.
  • Host genetics play a crucial role in the pathogenesis of COVID-19.

Conclusions:

  • Understanding coronavirus origins is vital for pandemic preparedness.
  • Diabetic individuals face increased COVID-19 severity due to viral impact on glucose metabolism and immune response.
  • Host genetics are a key determinant of COVID-19 outcomes, particularly in vulnerable populations like those with diabetes.
Keywords:
CoronavirusDiabetesMERSSARSSARS-CoV-2Single nucleotide polymorphism

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