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Papillary Dermis

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Isolated Palmoplantar Lentiginosis.

Faisal Alghubaywi^1,2, Mohammed I AlJasser^1,2,3, Majid Alfadhel^1,3,4

¹College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Clinical, Cosmetic and Investigational Dermatology

|July 3, 2023

Summary

This report details a unique case of lentigines isolated to the palms and soles in an otherwise healthy individual. This rare presentation of lentigo simplex expands understanding of lentigines distribution and associated conditions.

Keywords:

case report isolated lentiginosis palmoplantar

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Area of Science:

Dermatology
Genetics

Background:

Lentigines distribution can indicate underlying genetic or acquired conditions.
Understanding variations in lentigines presentation is crucial for accurate diagnosis.

Observation:

A unique case of lentigines exclusively on the palms and soles was observed in a healthy individual.
The patient had no significant personal or familial medical history.
Clinical examination and comprehensive genetic testing (whole-genome sequencing) revealed no abnormalities.

Findings:

The isolated palmoplantar distribution of lentigines was determined to be benign.
The presentation is consistent with lentigo simplex, but with an unprecedented distribution pattern.
No similar cases of palmoplantar-limited lentigines have been previously documented.

Implications:

This case broadens the known spectrum of lentigines presentations.
It highlights the importance of considering unusual distributions even in the absence of other symptoms.
Further research may explore genetic factors influencing localized lentigines patterns.