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The Claustrum Sign in Febrile Infection-Related Epilepsy Syndrome (FIRES).

Kelly Di Dier¹, Lucas Dekesel¹, Sven Dekeyzer¹

¹UZ Ghent, BE.

Journal of the Belgian Society of Radiology

|July 3, 2023

Summary

This summary is machine-generated.

Bilateral mesiotemporal edema and the claustrum sign are observed in febrile infection-related epilepsy syndrome (FIRES) and new onset refractory status epilepticus (NORSE). However, these imaging findings are not definitive for diagnosing these specific epilepsy conditions.

Keywords:

FIRES NORSE claustrum sign magnetic resonance imaging neuroradiology

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Published on: December 6, 2016

Area of Science:

Neurology
Neuroradiology
Epileptology

Background:

Febrile infection-related epilepsy syndrome (FIRES) and new onset refractory status epilepticus (NORSE) are severe neurological emergencies.
Identifying specific imaging biomarkers for FIRES and NORSE is crucial for timely diagnosis and management.

Observation:

Bilateral mesiotemporal edema is a notable finding on neuroimaging.
The "claustrum sign," characterized by T2 hyperintensity in the claustrum, is another observed radiological feature.

Findings:

Both bilateral mesiotemporal edema and the claustrum sign can be present in patients with FIRES.
These imaging findings are also observed in cases of NORSE.
Crucially, these radiological signs are not exclusive to FIRES or NORSE and lack diagnostic specificity.

Implications:

The presence of bilateral mesiotemporal edema or the claustrum sign should prompt consideration of FIRES and NORSE.
These findings alone are insufficient for a definitive diagnosis, necessitating a comprehensive clinical and diagnostic evaluation.
Further research is needed to identify more specific biomarkers for differentiating FIRES and NORSE from other encephalopathic conditions.