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B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
Daniel Gregório Gonsalves1, Paulo Eduardo Albuquerque Zito Raffa1, Gabriela Gerenutti de Sousa2
1Graduation Medicine at Faculty of Medicine of Catanduva, Catanduva, São Paulo, Brazil.
Asian Journal of Neurosurgery
|July 3, 2023
Summary
Intramedullary lymphoma, a rare spinal cord tumor, causes significant neurological deficits. This study reviews 25 cases, highlighting clinical features and treatment outcomes for this challenging condition.
Area of Science:
- Neurology
- Oncology
- Neurosurgery
Background:
- Intramedullary tumors are a primary cause of spinal cord injuries, presenting with symptoms like pain and progressive weakness.
- Intramedullary lymphoma is a rare but significant cause of spinal cord lesions, often mimicking other pathologies.
Purpose of the Study:
- To systematically review the clinical features and outcomes of primary intramedullary spinal cord lymphoma.
- To present a case of a large diffuse B-cell lymphoma infiltrating the spinal cord.
Main Methods:
- A systematic literature search was conducted using MEDLINE following PRISMA guidelines.
- Twenty-one studies reporting 25 cases of intramedullary lymphoma were included.
- Data extraction standardized clinical features, diagnosis, and treatment of included cases.
Main Results:
- The systematic review identified 25 cases of primary intramedullary spinal cord lymphoma.
- A presented case involved an 82-year-old woman with a large diffuse B-cell lymphoma causing Brown-Séquard syndrome.
- The patient showed partial symptom recovery with corticosteroids, but the lesion persisted, later confirmed by biopsy.
Conclusions:
- Primary intramedullary spinal cord lymphoma presents with diverse neurological symptoms and can be challenging to diagnose.
- Early diagnosis and appropriate treatment, including surgery and chemotherapy, are crucial for managing intramedullary lymphoma.
- Further research is needed to establish optimal treatment strategies for this rare condition.
