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Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
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Published on: February 21, 2019

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Regulation, targets and functions of CSK

Shudong Zhu1, Hui Wang1, Kamakshi Ranjan2

  • 1School of Medicine, Nantong University, Nantong, China.

Frontiers in Cell and Developmental Biology
|July 3, 2023
PubMed

Insights

C-terminal Src kinase (CSK) negatively regulates Src family kinases (SFKs), impacting numerous cellular processes. Dysregulation of CSK is linked to various diseases, with emerging research revealing novel targets and regulatory mechanisms.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Src family kinases (SFKs) are crucial in signal transduction, and their aberrant activation is implicated in diseases like cancer.
  • C-terminal Src kinase (CSK) acts as a key negative regulator of SFKs by phosphorylating them.
  • CSK, like Src, possesses SH3, SH2, and catalytic kinase domains, but its kinase domain is intrinsically inactive.

Purpose of the Study:

  • To review recent advancements in understanding C-terminal Src kinase (CSK).
  • To highlight the diverse physiological roles of CSK beyond its established interaction with SFKs.
  • To explore novel CSK targets and regulatory mechanisms.

Main Methods:

  • Literature review of recent scientific findings on CSK.
  • Analysis of studies investigating CSK's involvement in various physiological processes.
  • Examination of research on novel CSK-related targets and regulation.

Main Results:

  • CSK plays a critical role in DNA repair, intestinal epithelial cell permeability, synaptic activity, and immune responses.
  • Dysregulation of CSK is associated with diverse pathologies, including cancer and blood disorders.
  • Emerging evidence points to new CSK targets and regulatory pathways beyond the canonical CSK-SFK axis.

Conclusions:

  • CSK is a vital regulator with broad physiological functions, and its dysregulation contributes to multiple diseases.
  • Further research into novel CSK targets and regulatory mechanisms is essential for a comprehensive understanding.
  • CSK represents a promising area for therapeutic intervention in various disease contexts.
Keywords:
ChkCskSFKactivityregulationsrctarget

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