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Metabolomics in aging research: aging markers from organs.
Weicheng Fang1, Shuxin Chen1, Xuejiao Jin1
1State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou, China.
Frontiers in Cell and Developmental Biology
|July 3, 2023
Summary
Metabolic reprogramming drives aging, but organ-specific metabolite changes are complex. This review identifies key metabolites as potential aging biomarkers for future diagnostics and interventions.
Area of Science:
- Gerontology
- Metabolomics
- Systems Biology
Background:
- Metabolism is central to aging regulation, with metabolic reprogramming as a key driver.
- Tissue-specific metabolic needs complicate the relationship between metabolite levels and aging.
- Existing 'aging clocks' exist for genes, proteins, and epigenetics, but not metabolism.
Purpose of the Study:
- To systematically review recent metabolomic changes during organismal aging.
- To identify frequently altered metabolites as potential aging biomarkers.
- To explore the in vivo roles of these metabolites in aging.
Main Methods:
- Literature review of metabolomic studies on aging published in the last decade.
- Analysis of metabolite level changes across different organs during aging.
- Discussion of the functional roles of high-repetition metabolites.
Main Results:
- Metabolomic research provides insights into organismal metabolic shifts during aging.
- Several metabolites show consistent changes across aging studies.
- Understanding these metabolic markers is crucial for aging research.
Conclusions:
- Metabolomics offers a novel approach to understanding aging.
- Identified metabolites may serve as reliable aging biomarkers.
- This knowledge can inform clinical interventions for aging and related diseases.
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