Related Experiment Videos
Plasma kinetics of DDAVP in man
Acta Pharmacologica Et Toxicologica
|May 1, 1986
Summary
This study determined the pharmacokinetics of desmopressin (DDAVP) in healthy volunteers. DDAVP demonstrated a total clearance of 2.6 ml/min/kg and a plasma half-life of 55 minutes.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Metabolism
Background:
- Desmopressin (DDAVP) is a synthetic analogue of vasopressin used clinically.
- Understanding DDAVP pharmacokinetics is crucial for optimizing therapeutic use.
Purpose of the Study:
- To characterize the pharmacokinetic profile of desmopressin (DDAVP) following intravenous infusion in healthy individuals.
Main Methods:
- Normal volunteers received a bolus injection of DDAVP followed by a 3.5-hour infusion.
- Blood samples were collected during and post-infusion.
- DDAVP concentrations were quantified using radioimmunoassay (RIA).
Main Results:
- The total clearance of DDAVP was determined to be 2.6 ml/min/kg body weight.
- The plasma half-life of DDAVP was measured at 55 minutes.
Conclusions:
- The study provides key pharmacokinetic parameters for DDAVP.
- These findings contribute to the understanding of DDAVP disposition in humans.