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Mitochondrial homeostasis: a potential target for delaying renal aging
Ming Yang1,2, Chongbin Liu1,2, Na Jiang1,2
1Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
Frontiers in Pharmacology
|July 3, 2023
Summary
Mitochondrial health is crucial for kidney function during aging. Maintaining mitochondrial homeostasis, including function and reducing oxidative stress, may prevent age-related kidney decline.
Area of Science:
- Cellular Biology
- Gerontology
- Nephrology
Background:
- Mitochondria are vital for cellular energy and abundant in the kidney.
- Renal aging involves degenerative processes and accumulating damage.
- Abnormal mitochondrial homeostasis is increasingly linked to kidney aging.
Purpose of the Study:
- To review biochemical markers of aging.
- To examine structural and functional renal changes during aging.
- To detail the role of mitochondrial homeostasis in renal aging.
Main Methods:
- Literature review of aging markers.
- Analysis of age-related changes in kidney structure and function.
- Review of mitochondrial function, mitophagy, oxidative stress, and inflammation in renal aging.
Main Results:
- Aging is associated with specific biochemical markers and altered kidney structure/function.
- Mitochondrial dysfunction, impaired mitophagy, and increased oxidative stress/inflammation contribute to renal aging.
- Current anti-aging compounds targeting mitochondria are discussed.
Conclusions:
- Mitochondrial homeostasis plays a significant role in renal aging.
- Maintaining mitochondrial health is a promising strategy to combat age-related kidney decline.
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