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Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy.
Gurneel K Dhanesar1, Jonathan Livingston1, Michael Maroules2
1Internal Medicine, New York Medical College at St. Mary's General Hospital, Passaic and St. Clare's Health, Denville, USA.
Cureus
|July 3, 2023
Summary
Hairy cell leukemia (HCL) can relapse in the liver's portal system, even after splenectomy. This rare hepatic involvement highlights the need for further research into HCL's behavior.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Hairy cell leukemia (HCL) is a rare B-cell neoplasm.
- Splenectomy is a treatment for HCL-related cytopenia.
- Hepatic involvement in HCL is uncommon and poorly understood.
Observation:
- A case study of an 88-year-old male with a history of splenectomy.
- The patient presented with a relapse of classic hairy cell leukemia.
- The leukemia infiltrated the hepatic portal system.
Findings:
- This case demonstrates rare hepatic portal system involvement of hairy cell leukemia.
- Sinusoidal endothelial cell infiltration was observed in the liver.
- Relapse occurred despite previous splenectomy.
Implications:
- Highlights the potential for HCL to involve the liver, even after spleen removal.
- Suggests the hepatic portal system as a site for HCL relapse.
- Underscores the need for better understanding and diagnostic approaches for rare HCL manifestations.
