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Related Experiment Video

Updated: Jul 24, 2025

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Published on: February 10, 2018

Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy.

Gurneel K Dhanesar¹, Jonathan Livingston¹, Michael Maroules²

¹Internal Medicine, New York Medical College at St. Mary's General Hospital, Passaic and St. Clare's Health, Denville, USA.

|July 3, 2023

Summary

Hairy cell leukemia (HCL) can relapse in the liver's portal system, even after splenectomy. This rare hepatic involvement highlights the need for further research into HCL's behavior.

Keywords:

bcell cytopenia hairy cell leukemia hematology-oncology hepatology lymphoma oncology rituximab splenectomy vemurafenib

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Published on: June 11, 2019

Area of Science:

Hematology
Oncology
Pathology

Background:

Hairy cell leukemia (HCL) is a rare B-cell neoplasm.
Splenectomy is a treatment for HCL-related cytopenia.
Hepatic involvement in HCL is uncommon and poorly understood.

Observation:

A case study of an 88-year-old male with a history of splenectomy.
The patient presented with a relapse of classic hairy cell leukemia.
The leukemia infiltrated the hepatic portal system.

Findings:

This case demonstrates rare hepatic portal system involvement of hairy cell leukemia.
Sinusoidal endothelial cell infiltration was observed in the liver.
Relapse occurred despite previous splenectomy.

Implications:

Highlights the potential for HCL to involve the liver, even after spleen removal.
Suggests the hepatic portal system as a site for HCL relapse.
Underscores the need for better understanding and diagnostic approaches for rare HCL manifestations.