Related Experiment Video
Updated: Jul 24, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
A Case Report of Generalized Non-pruritic Lichen Amyloidosis
Morgan A Rousseau1, Stephanie A Valek1, Rashid M Rashid2
1Dermatology, University of Texas Health Science Center, Houston, USA.
Abstract:
We evaluate the rare case of a patient who presented with generalized, non-pruritic lichen amyloidosis. There are three reported cases of generalized and non-pruritic lichen amyloidosis. The lichen amyloidosis subtype of primary localized cutaneous amyloidosis is characterized by keratinocyte-derived amyloid deposition in the papillary dermis, classically presenting as pruritic, hyperpigmented macules coalescing into plaques on the lower extremities. While the pathogenesis is likely multifactorial, chronic scratching has been proposed as an inciting factor. The patient's type of lichen amyloidosis challenges the proposed etiology of chronic scratching leading to amyloid deposition.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Amyloid Fibrils
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management

