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Updated: Jul 24, 2025

08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
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Personalized Tacrolimus Dosing After Liver Transplantation: A Randomized Clinical Trial.
Medrxiv : the Preprint Server for Health Sciences
|July 3, 2023
Summary
Phenotypic Personalized Medicine (PPM) improves tacrolimus dosing after liver transplant, reducing large deviations from target drug levels. This approach offers actionable daily recommendations, enhancing drug level maintenance compared to standard care.
Area of Science:
- Pharmacology
- Transplantation Medicine
- Personalized Medicine
Background:
- Tacrolimus dosing variability necessitates improved methods for individualized patient management.
- Current empirical dosing often leads to suboptimal drug trough levels.
- Phenotypic Personalized Medicine (PPM) offers a novel approach to optimize tacrolimus therapy.
Conclusions:
- PPM-guided tacrolimus dosing significantly improves drug level maintenance compared to standard care.
- The PPM approach provides dynamic, actionable dosing recommendations for daily management.
- This strategy may contribute to better patient outcomes and resource utilization in liver transplantation.
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