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Updated: Jul 24, 2025
08:32
Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
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The Effects of Nitric Oxide on Choroidal Gene Expression
Makenzie B Merkley1, Diana Soriano2, Kenneth L Jones3
1Department of Biology, University of Oklahoma, Norman, Oklahoma, 73019, United States.
Biorxiv : the Preprint Server for Biology
|July 3, 2023
Summary
Nitric oxide (NO) influences eye growth by altering choroidal gene expression. This study reveals NO's role in regulating genes linked to cell death and proliferation, offering insights into myopia development.
Area of Science:
- Ophthalmology and Vision Science
- Molecular Biology
- Genomics
Background:
- Nitric oxide (NO) is a key biological mediator with emerging roles in physiological functions.
- Evidence suggests NO involvement in postnatal ocular growth and myopia development.
- Understanding NO's role in visually-guided eye growth is crucial for myopia research.
Conclusions:
- NO significantly impacts choroidal gene expression, affecting pathways related to cell death and proliferation.
- These findings may inform targeted therapies for myopia and other ocular diseases.
- NO's role in the choroid is important for visually regulated eye growth.
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