Metastatic HER2 lacrimal/salivary gland duct adenocarcinoma
Ruaa Abdullah Mansi1, Bríd Morris2, Tim Fulcher2
1Internal Medicine, Royal College of Physicians of Ireland, and Taibah University, Dublin, and Madina, Ireland, and Saudi Arabia ruaa.mansi@hse.ie.
Abstract:
In this report, we present a case of a patient with a 30-year history of orbital asymmetry who presented with metastatic human epidermal growth factor receptor 2 (HER2) positive lacrimal/salivary gland ductal adenocarcinoma. The patient was treated with chemoradiotherapy and trastuzumab. Tumours of lacrimal gland origin are rare, and unfortunately can frequently present in late stage. There are no current guidelines on the optimal treatment of metastatic lacrimal gland tumours, in particular those with HER2 amplified malignancy. This case highlights a unique presentation of a rare disease, and the potential for targeted therapy.
Insights
This report details a rare case of metastatic human epidermal growth factor receptor 2 (HER2)-positive lacrimal gland adenocarcinoma. Treatment involved chemoradiotherapy and trastuzumab, showing potential for targeted therapy in advanced cases.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Lacrimal gland ductal adenocarcinoma is a rare malignancy.
- These tumours often present at a late stage, posing treatment challenges.
- Optimal treatment strategies for metastatic and HER2-amplified cases are not well-defined.
Observation:
- A patient with a 30-year history of orbital asymmetry presented with metastatic lacrimal/salivary gland ductal adenocarcinoma.
- The tumour was identified as human epidermal growth factor receptor 2 (HER2)-positive.
Findings:
- The patient received treatment with chemoradiotherapy and trastuzumab.
- This therapeutic approach demonstrated potential in managing this rare, advanced malignancy.
Implications:
- This case highlights a unique presentation of a rare cancer.
- Targeted therapy, such as trastuzumab for HER2-positive tumours, shows promise.
- Further research is needed to establish treatment guidelines for metastatic lacrimal gland tumours.
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