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Necrotizing enterocolitis in infants of multiple gestation.
American Journal of Diseases of Children (1960)
|September 1, 1986
Summary
Firstborn infants in twin and triplet sets were more likely to develop necrotizing enterocolitis (NEC), despite appearing more stable. Unrecognized risk factors likely contribute to NEC pathogenesis in premature infants.
Area of Science:
- Neonatal Medicine
- Pediatric Gastroenterology
- Perinatal Research
Background:
- Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition affecting premature infants.
- The pathogenesis of NEC is not fully understood, and risk factors are actively investigated.
Purpose of the Study:
- To investigate the incidence and potential risk factors for NEC in multiple births (twins and triplets).
- To identify any disparities in NEC development between siblings within the same multiple birth set.
Main Methods:
- Retrospective review of medical records for ten twin pairs and one set of triplets with at least one infant diagnosed with NEC.
- Comparison of clinical characteristics and outcomes between affected and unaffected infants within each set.
Main Results:
- Firstborn infants in multiple sets showed a higher incidence of NEC compared to their later-born siblings.
- Despite appearing more stable, firstborn infants had lower rates of perinatal asphyxia and respiratory distress.
- Firstborn infants were fed sooner and advanced feedings more rapidly than their counterparts.
Conclusions:
- The study highlights unrecognized risk factors contributing to NEC development.
- A high index of suspicion for NEC is crucial in all premature infants, even those appearing clinically stable.
- Findings suggest a complex interplay of factors beyond apparent clinical stability in NEC pathogenesis.