Related Experiment Video
Updated: Jul 24, 2025
10:27
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
7.3K
Wargaming cancer: a strategy for future precision oncology?
Tony Ingesson1, David Gisselsson2
1Department of Political Science, Lund University, 22100 Lund, Sweden.
Trends in Cancer
|July 3, 2023
Summary
Drug resistance in precision oncology requires new strategies. This study uses military and espionage concepts to find cancer vulnerabilities and trick its evolution into evolutionary dead ends.
Area of Science:
- Oncology
- Evolutionary Biology
- Systems Biology
Background:
- Drug resistance is a significant challenge in precision oncology.
- Current treatment strategies require re-evaluation to overcome resistance.
- Understanding cancer's dynamic interaction with the host is crucial.
Purpose of the Study:
- To apply military and espionage theories to cancer treatment.
- To identify system vulnerabilities in cancer evolution.
- To develop strategies for tricking cancer into evolutionary dead ends.
Main Methods:
- Conceptual framework applying military theory to cancer dynamics.
- Analysis of host-cancer interactions through an evolutionary lens.
- Identification of cancer's adaptive vulnerabilities.
Main Results:
- Novel insights into cancer as a dynamic, evolving adversary.
- Identification of specific vulnerabilities exploitable through strategic interventions.
- Conceptual pathways to induce evolutionary collapse in cancer.
Conclusions:
- A novel theoretical framework for combating cancer drug resistance.
- Potential for innovative therapeutic strategies inspired by military and espionage tactics.
- Future research directions in evolutionary oncology and strategic cancer therapy.
Related Concept Videos
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
01:21Cancer Survival Analysis
397
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
397
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
573
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
573
01:30Cancer Vaccines
428
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
428
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K