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Myoglobinuria in chronic renal failure.
Summary
Chronic renal failure increases serum myoglobin (hypermyoglobinemia) and often leads to myoglobinuria. As kidney function declines, the kidneys reabsorb less filtered myoglobin.
Area of Science:
- Nephrology
- Clinical Biochemistry
Background:
- Myoglobin is a protein found in muscle tissue.
- Elevated myoglobin levels can indicate muscle damage.
- Renal failure affects the clearance of various substances from the blood.
Purpose of the Study:
- To investigate serum and urine myoglobin levels in patients with chronic renal failure.
- To determine the relationship between renal function and myoglobin excretion.
Main Methods:
- Serum and urine myoglobin levels were measured in 14 patients with stable chronic renal failure.
- Fractional excretion of myoglobin was calculated.
- Creatinine clearance was assessed to evaluate renal function.
Main Results:
- Serum myoglobin levels ranged from 38 to 350 ng/mL.
- Eleven patients exhibited myoglobinuria (urine myoglobin 15-250 ng/mL).
- Fractional myoglobin excretion increased with decreased creatinine clearance, indicating reduced renal reabsorption.
Conclusions:
- Chronic renal failure causes hypermyoglobinemia and frequently results in myoglobinuria.
- Diminished renal function leads to decreased reabsorption of filtered myoglobin by surviving nephrons.