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Related Experiment Videos

Myoglobinuria in chronic renal failure.

D A Feinfeld, A M Briscoe, H M Nurse

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |August 1, 1986
    PubMed
    Summary

    Chronic renal failure increases serum myoglobin (hypermyoglobinemia) and often leads to myoglobinuria. As kidney function declines, the kidneys reabsorb less filtered myoglobin.

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    Area of Science:

    • Nephrology
    • Clinical Biochemistry

    Background:

    • Myoglobin is a protein found in muscle tissue.
    • Elevated myoglobin levels can indicate muscle damage.
    • Renal failure affects the clearance of various substances from the blood.

    Purpose of the Study:

    • To investigate serum and urine myoglobin levels in patients with chronic renal failure.
    • To determine the relationship between renal function and myoglobin excretion.

    Main Methods:

    • Serum and urine myoglobin levels were measured in 14 patients with stable chronic renal failure.
    • Fractional excretion of myoglobin was calculated.
    • Creatinine clearance was assessed to evaluate renal function.

    Main Results:

    • Serum myoglobin levels ranged from 38 to 350 ng/mL.
    • Eleven patients exhibited myoglobinuria (urine myoglobin 15-250 ng/mL).
    • Fractional myoglobin excretion increased with decreased creatinine clearance, indicating reduced renal reabsorption.

    Conclusions:

    • Chronic renal failure causes hypermyoglobinemia and frequently results in myoglobinuria.
    • Diminished renal function leads to decreased reabsorption of filtered myoglobin by surviving nephrons.

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