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Longevity factor klotho enhances cognition in aged nonhuman primates.
Stacy A Castner1, Shweta Gupta2, Dan Wang2
1Department of Psychiatry and VA Connecticut Healthcare System, Yale School of Medicine, West Haven, CT, USA.
Nature Aging
|July 3, 2023
Summary
Klotho, a longevity factor, improved memory and synaptic plasticity in mice. Low-dose klotho treatment enhanced memory in aged nonhuman primates, suggesting therapeutic potential for human aging.
Area of Science:
- Gerontology
- Neuroscience
- Biomedical Research
Background:
- Cognitive dysfunction is a significant challenge in aging.
- The therapeutic potential of klotho, a longevity factor, for cognitive enhancement remains unexplored in human-relevant models.
- There is a critical knowledge gap regarding klotho's effects on cognition in primates.
Purpose of the Study:
- To investigate the effects of klotho on cognitive function and synaptic plasticity.
- To determine if klotho can enhance cognition in aged nonhuman primates.
- To assess the therapeutic potential of klotho for age-related cognitive decline.
Main Methods:
- Validated the rhesus form of klotho protein in mouse models.
- Assessed the impact of klotho on synaptic plasticity and cognition in mice.
- Administered single doses of low-dose and high-dose klotho to aged nonhuman primates.
- Evaluated memory enhancement in nonhuman primates following klotho administration.
Main Results:
- Klotho treatment increased synaptic plasticity and cognition in mice.
- A single administration of low-dose klotho, but not high-dose, enhanced memory in aged nonhuman primates.
- The findings demonstrate a dose-dependent effect of klotho on cognitive function.
Conclusions:
- Systemic low-dose klotho treatment shows promise for enhancing memory in aged nonhuman primates.
- Klotho may represent a viable therapeutic strategy for combating cognitive dysfunction in aging humans.
- Further research is warranted to explore klotho's therapeutic applications in human aging.
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