Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nifedipine overdose.

D M Herrington, B M Insley, G G Weinmann

    The American Journal of Medicine
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Nifedipine overdose in a 59-year-old man caused severe hypotension and heart dysfunction. Aggressive treatment with fluids, calcium, and dopamine proved effective, highlighting management strategies for calcium channel blocker toxicity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The association of calcium supplementation and incident cardiovascular events in the Multi-ethnic Study of Atherosclerosis (MESA).

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2016
    Same author

    C-reactive protein concentration predicts mortality in type 2 diabetes: the Diabetes Heart Study.

    Diabetic medicine : a journal of the British Diabetic Association·2012
    Same author

    The relationship between inflammation, obesity and risk for hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA).

    Journal of human hypertension·2010
    Same author

    The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: results from the SMILE-Platelets project.

    Journal of thrombosis and haemostasis : JTH·2010
    Same author

    Endothelial dysfunction is associated with left ventricular mass (assessed using MRI) in an adult population (MESA).

    Journal of human hypertension·2010
    Same author

    Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study.

    Annals of human genetics·2008

    Area of Science:

    • Cardiology
    • Clinical Pharmacology
    • Toxicology

    Background:

    • Calcium channel blockers, specifically nifedipine, are widely prescribed for cardiovascular conditions.
    • Overdose cases necessitate understanding the toxicological profile and effective management strategies.

    Observation:

    • A 59-year-old male presented with profound hypotension, sinus node dysfunction, and atrioventricular node dysfunction after ingesting 900 mg of nifedipine.
    • Hyperglycemia was also noted as a significant metabolic disturbance.

    Findings:

    • The patient's condition significantly improved with aggressive intravenous fluid resuscitation, calcium administration, and dopamine infusion.
    • Reported cases of verapamil overdose share similar cardiovascular effects and therapeutic responses.

    Related Experiment Videos

    Implications:

    • Nifedipine overdose can lead to life-threatening hypotension and cardiac conduction abnormalities.
    • Prompt and aggressive medical management, including fluids, calcium, and inotropes like dopamine, is crucial for favorable outcomes.
    • As the use of calcium channel blockers increases, clinicians should anticipate and be prepared for overdose scenarios.