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Investigating the correlation between Xrn1-resistant RNAs and frameshifter pseudoknots

Ivar W Dilweg1, Megan G Oskam1, Sophie Overbeek1

  • 1Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

RNA Biology
|July 4, 2023
PubMed
Summary

The coremin motif in viral RNA can cause ribosomal frameshifting and resist degradation by the Xrn1 enzyme. This study reveals that Xrn1-resistant RNAs universally promote frameshifting, but Xrn1 resistance involves more than just frameshifting pseudoknots.

Keywords:
RNA pseudoknotXrn1Zika viruscoremin motifribosomal frameshifting

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